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Monday, January 23, 2012
Bad Girls Club Season 8 Premiere
Oxygen’s “Bad Girls Club” takes on an all new city with a hot new cast and a wild Las Vegas location. A brand new group of seven young women travel to Las Vegas and – in a series first – two of the girls are sisters…twins! On the season premiere, the seven girls are off [...]
FACT CHECK: History flubs in Republican debate (AP)
WASHINGTON ? Mitt Romney perpetuated one unsubstantiated claim, about his record at Bain Capital, and more or less corrected himself on another, about President Barack Obama's health care law, in the latest Republican presidential debate.
His rivals flubbed history, Newt Gingrich blaming a Democratic president for a jobless rate he never had, and Ron Paul painting an idyllic picture of life before Medicare that did not reflect deprivations of that time.
A look at some of the claims in the debate Thursday night and how they compare with the facts:
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ROMNEY: "We started a number of businesses; four in particular created 120,000 jobs, as of today. We started them years ago. They've grown ? grown well beyond the time I was there to 120,000 people that have been employed by those enterprises. ... Those that have been documented to have lost jobs, lost about 10,000 jobs. So (120,000 less 10,000) means that we created something over 100,000 jobs."
THE FACTS: Romney now has acknowledged the negative side of the ledger from his years with Bain Capital, but hardly laid out the full story. His claim to have created more than 100,000 jobs in the private sector as a venture capitalist remains unsupported.
Romney mentioned four successful investments in companies that now employ some 120,000 people, having grown since he was involved in them a decade or ago or longer. From that, he subtracted the number of jobs that he said are known to have been lost at certain other companies.
What's missing is anything close to a complete list of winners and losers ? and the bottom line on jobs. Bain under Romney invested in scores of private companies that don't have the obligation of big publicly traded corporations to disclose finances. Romney acknowledged that he was using current employment figures for the four companies, not the number of jobs they had when he left Bain Capital, yet took credit for them in his analysis.
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GINGRICH: "Under Jimmy Carter, we had the wrong laws, the wrong regulations, the wrong leadership, and we killed jobs. We had inflation. We went to 10.8 percent unemployment. Under Ronald Reagan, we had the right job ? the right laws, the right regulators, the right leadership. We created 16 million new jobs."
THE FACTS: Sure, inflation was bad and gas lines long, but under Carter's presidency unemployment never topped 7.8 percent. The unemployment rate did reach 10.8 percent, but not until November 1982, nearly two years into Reagan's first term.
Most economists attribute the jobless increase to a sharp rise in interest rates engineered by then-Federal Reserve Chairman Paul Volcker in an ultimately successful effort to choke off inflation. Unemployment began to fall in 1983 and dropped to 7.2 percent in November 1984, when Reagan easily won re-election.
The economy did add 16 million jobs during Reagan's 1981-1989 presidency. Gingrich's assertion that "we created" them may have left the impression that he was a key figure in that growth. Although Gingrich was first elected to the House in 1978, his first Republican leadership position, as minority whip, began when Reagan left office, in 1989.
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PAUL: "I had the privilege of practicing medicine in the early `60s, before we had any government (health care). It worked rather well, and there was nobody on the street suffering with no medical care. But Medicare and Medicaid came in and it just expanded."
THE FACTS: Before Medicare was created in the mid-1960s, only about half of the elderly had private insurance for hospital care, and they were facing rising costs for those policies on their fixed incomes. Medicare was hugely contentious at the time, seen by many doctors as a socialist takeover, but few argued that the status quo could be maintained.
A Health, Education and Welfare Department report to Congress in 1959, during the Republican administration of Dwight Eisenhower, took no position on what the federal government should do but stated "a larger proportion of the aged than of other persons must turn to public assistance for payment of their medical bills or rely on `free' care from hospitals and physicians."
Paul advocates a return to an era when doctors would treat the needy for free. But even in the old days, charity came with a cost. Research from the pre-Medicare era shows that the cost of free care was transferred to paying customers and the insurance industry.
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ROMNEY: "I could have stayed in Detroit, like him, and gotten pulled up in the car company. I went off on my own. I didn't inherit money from my parents. What I have, I earned. I worked hard, the American way."
THE FACTS: It's true there's no evidence Romney's wealthy family gave him a trust fund, or helped him secure a job at Bain Capital, where he would ultimately make his fortune. But it's not entirely the case that his success is wholly the result of his own hard work.
Romney's father, George, was an automobile industry CEO and a Michigan governor. He paid for Mitt to attend the Cranbrook School, a private boarding school in the Detroit area. The education didn't hurt Romney's ability to get into Harvard, where he earned law and business degrees in 1975.
While Romney appears to have gotten a job at Bain out of college on his own, the Boston Globe book "The Real Romney" reports that Romney's parents helped him and his wife buy their first home when he was in his early 20s.
On Thursday night, the Romney campaign did not dispute the finding that Romney's parents helped pay for that house, in the Boston suburb of Belmont.
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ROMNEY: "The executive order is a beginning process. It's one thing, but it doesn't completely eliminate Obamacare. ... We have to go after a complete repeal. And that's going to have to have to happen with a House and a Senate, hopefully, that are Republican."
THE FACTS: With that statement, Romney essentially corrected his repeated suggestions in early debates and speeches that he would eliminate President Barack Obama's health care law with a stroke of the pen on his first day in office ? a power no president has.
In one variation of the claim, he had vowed in a Sept. 7 debate that on Day One, he would sign an executive order "granting a waiver from Obamacare to all 50 states." This, despite the fact that the law lays out an onerous process for letting individual states off the hook from its requirements, and that process cannot begin until 2017.
Now he acknowledges the political reality that a Republican president would need Republican control of Congress to have a strong shot at repealing the law.
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Associated Press writers Steve Peoples, Jim Drinkard, and Christopher S. Rugaber contributed to this report.
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Sunday, January 22, 2012
Investigators achieve important step toward treating Huntington's disease
ScienceDaily (Jan. 19, 2012) ? A team of researchers at the UC Davis Institute for Regenerative Cures has developed a technique for using stem cells to deliver therapy that specifically targets the genetic abnormality found in Huntington's disease, a hereditary brain disorder that causes progressive uncontrolled movements, dementia and death.
The findings, now available online in the journal Molecular and Cellular Neuroscience, suggest a promising approach that might block the disease from advancing.
"For the first time, we have been able to successfully deliver inhibitory RNA sequences from stem cells directly into neurons, significantly decreasing the synthesis of the abnormal huntingtin protein," said Jan A. Nolta, principal investigator of the study and director of the UC Davis stem cell program and the UC Davis Institute for Regenerative Cures. "Our team has made a breakthrough that gives families affected by this disease hope that genetic therapy may one day become a reality."
Huntington's disease can be managed with medications, but currently there are no treatments for the physical, mental and behavioral decline of its victims. Nolta and other experts think the best chance to halt the disease's progression will be to reduce or eliminate the mutant huntingtin (htt) protein found in the neurons of those with the disease. RNA interference (RNAi) technology has been shown to be highly effective at reducing htt protein levels and reversing disease symptoms in mouse models.
"Our challenge with RNA interference technology is to figure out how to deliver it into the human brain in a sustained, safe and effective manner," said Nolta, whose lab recently received funding from the California Institute for Regenerative Medicine to develop an RNAi delivery system for Huntington's disease. "We're exploring how to use human stem cells to create RNAi production factories within the brain."
Huntington's disease affects more than a quarter of a million Americans. The disorder can be passed down through families even if only one parent has the abnormal huntingtin gene. The disease is caused by a mutation in the gene, which is composed of an abnormally repeating building block of DNA that appears on the fourth chromosome. While the building block pattern normally repeats up to 28 times on the chromosome, too many repeats cause an abnormal form of protein -- known as the huntingtin protein -- to be made. The huntingtin protein accumulates in the brain, causing the disease's devastating progression. Individuals usually develop symptoms in middle age if there are more than 35 repeats. A more rare form of the disease occurs in youth when the abnormal DNA pattern repeats many more times.
The UC Davis research team showed for the first time that inhibitory RNA sequences can be transferred directly from donor cells into target cells to greatly reduce unwanted protein synthesis from the mutant gene. To transfer the inhibitory RNA sequences into their targets, Nolta's team genetically engineered mesenchymal stem cells (MSCs), which were derived from the bone marrow of unaffected human donors. Over the past two decades, Nolta and her colleagues have shown MSCs to be safe and effective vehicles to deliver enzymes and proteins to other cells. She said finding that MSCs can also transfer RNA molecules directly from cell to cell, in amounts sufficient to reduce levels of a mutant protein by over 50 percent in the target cells, is a discovery that has never been reported before and offers great promise for a variety of disorders.
"Not only is finding new treatments for Huntington's disease a worthwhile pursuit on its own, but the lessons we are learning are applicable to developing new therapies for other genetic disorders that involve excessive protein development and the need to reduce it," said Nolta, who recently received a Transformative Research Grant from the National Institutes of Health to study how mesenchymal stem cells can transfer microRNA and other factors into the cells of damaged tissues, and how that process can be harnessed to treat injuries and disease. "We have high hopes that these techniques may also be utilized in the fight against some forms of amyotrophic lateral sclerosis (Lou Gehrig's disease) as well as Parkinson's and other conditions."
The article, "Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin," was co-authored by Scott D. Olson, now with Texas Medical Center in Houston. Other authors were Amal Kambal, now at Washington University in St. Louis; and Kari Pollock, Gaela-Marie Mitchell, Heather Stewart, Stefanos Kalomoiris, Whitney Cary, Catherine Nacey and Karen Pepper, with the UC Davis Institute for Regenerative Cures. Funding for the research was provided by the California Institute for Regenerative Medicine and Team KJ.
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The above story is reprinted from materials provided by University of California - Davis Health System.
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Journal Reference:
- Scott D. Olson, Amal Kambal, Kari Pollock, Gaela-Marie Mitchell, Heather Stewart, Stefanos Kalomoiris, Whitney Cary, Catherine Nacey, Karen Pepper, Jan A. Nolta. Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington's disease affected neuronal cells for reduction of huntingtin. Molecular and Cellular Neuroscience, 2011; DOI: 10.1016/j.mcn.2011.12.001
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://www.sciencedaily.com/releases/2012/01/120119163253.htm
Chemical in personal care products (phthalates) may contribute to child obesity
ScienceDaily (Jan. 20, 2012) ? Researchers from the Children's Environmental Health Center at The Mount Sinai Medical Center in New York have found an association between exposure to the chemical group known as phthalates and obesity in young children -- including increased body mass index (BMI) and waist circumference.
Phthalates are human-made, endocrine-disrupting chemicals that can mimic the body's natural hormones. They are commonly used in plastic flooring and wall coverings, food processing materials, medical devices, and personal-care products. While poor nutrition and physical inactivity are known to contribute to obesity, a growing body of research suggests that environmental chemicals -- including phthalates -- could play a role in rising childhood obesity rates.
This study was the first to examine the relationship between phthalate exposure and measurements used to identify obesity in children.
Mount Sinai researchers measured phthalate concentrations in the urine of 387 black and Hispanic children in New York City, and recorded body measurements including BMI, height, and waist circumference one year later. The urine tests revealed that greater than 97 percent of study participants had been exposed to phthalates typically found in personal care products such as perfume, lotions, and cosmetics; varnishes; and medication or nutritional supplement coatings. The phthalates included monoethyl phthalate (MEP) and other low molecular-weight phthalates. The team also found an association between concentrations of these phthalates with BMI and waist circumference among overweight children. For example, BMI in overweight girls with the highest exposure to MEP was 10 percent higher than those with the lowest MEP exposure.
"Research has shown that exposure to these everyday chemicals may impair childhood neurodevelopment, but this is the first evidence demonstrating that they may contribute to childhood obesity," said the study's lead author Susan Teitelbaum, PhD, Associate Professor in the Department of Preventive Medicine at Mount Sinai School of Medicine. "This study also further emphasizes the importance of reducing exposure to these chemicals where possible."
The percentage of obese children ages six to 11 in the United States has grown from seven percent in 1980 to more than 40 percent in 2008, according to the U.S. Centers for Disease Control and Prevention. More than 15 percent of American children between the ages six and 19 are characterized as obese. In New York City, more than one in five children in public schools are obese.
Dr. Teitelbaum and the team at the Children's Environmental Health Center plan to further evaluate the impact of these chemicals on childhood obesity. "While the data are significant, more research is needed to definitively determine whether phthalate exposure causes increases in body size," she said.
The paper is available online in the journal Environmental Research. The project was funded by the National Institute for Environmental Health Sciences, the National Cancer Institute, and the U.S. Environmental Protection Agency.
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The above story is reprinted from materials provided by Mount Sinai Medical Center, via Newswise.
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Journal Reference:
- Susan L. Teitelbaum, Nancy Mervish, Erin L. Moshier, Nita Vangeepuram, Maida P. Galvez, Antonia M. Calafat, Manori J. Silva, Barbara L. Brenner, Mary S. Wolff. Associations between phthalate metabolite urinary concentrations and body size measures in New York City children. Environmental Research, 2012; DOI: 10.1016/j.envres.2011.12.006
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://www.sciencedaily.com/releases/2012/01/120120182729.htm
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Saturday, January 21, 2012
Shannon Magrane Wows American Idol Judges, Earns Creepy Steven Tyler Praise
Shannon Magrane made quite the impression on American Idol judges during last night's season 11 premiere.
Awkwardly for the 15-year old's father, though, it wasn't simply due to her singing.
In a clearly contrived set-up, Randy asked Shannon after her athletic interests... which led to a mention that her dad, Joe, pitched in the 1987 World Series... which led to Joe and other family members entering the room... which led to Joe asking Steven Tyler about Boston and the Aerosmith frontman responding:
"Great, beautiful. Hot, humid and happening... just like your daughter!"
But let's not let that quip detract from Magrane's performance, as she earned a ticket to Hollywood due to a cover of "Something's Got a Hold on Me." We'll be keeping an eye on Shannon, just not in the way Tyler implied above.
Remaining our overall favorite from Savannah, though? Phillip Phillips, by a long shot.
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Friday, January 20, 2012
[OOC] Through the Looking Glass
Forum rules
This forum is for OOC discussion about existing roleplays.
This is the auto-generated OOC topic for the roleplay "Through the Looking Glass"
It's an interesting idea, but within the roleplay it'll be very impractical. Once the reality switch happens, it'll be very difficult to pull off the "walking around in New York without legs" aspect.
Subitted mine.
This forum is for OOC discussion about existing roleplays.
Please post all "Players Wanted" threads in the Roleplayers Wanted forum!
This topic is an Out Of Character part of the roleplay, ?Through the Looking Glass?. Anything posted here will also show up there.Topic Tags:
Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.This is the auto-generated OOC topic for the roleplay "Through the Looking Glass"
Use this to discuss the plot, have fun, and get to know each other. Anyone thinking of submitting a character can ask about the concept here! Currently, we have:
Real World:
Sibyl Volur
Sarah Hoffmann
Fantasy World:
Queen Abela Grimhild
Queen Miranda Wilster
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LSunday - Member for 1 years
Interesting, was wondering if I could be the little mermaid in the fairy tale world and the real world character is a marine biologist.
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snipergirl24 - Member for 1 years
It's an interesting idea, but within the roleplay it'll be very impractical. Once the reality switch happens, it'll be very difficult to pull off the "walking around in New York without legs" aspect.
To help clarify, the two characters are actually switching bodies. Meaning, if you are a mermaid, you will switch into the real world with a flipper, and the real world character will appear underwater.
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LSunday - Member for 1 years
I think it can be worked out if when the mermaid walks onto land her fins turn to legs ::crosses fingers::
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snipergirl24 - Member for 1 years
Subitted mine.
I has a question, is this based off the book The Looking Glas Wars? c:
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AliceHearts - Member for 0 years
I'll tell you what I'll go ahead and make the character and if you still don't think it will work after I iron out the details of it thats fine. But atleast give me a chance to work out the mechanics of the characters.
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snipergirl24 - Member for 1 years
That's fine. Looking forward to seeing the character!
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LSunday - Member for 1 years
Post a reply
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Sunday, January 1, 2012
Fed Court Grants Legal Immunity to Telecoms in Wiretapping Case ...
Originally posted by Joki42
What lies beneath the media fed to the public? What is really going on that we are not allowed to see?
I would say this gives companies legal rights to:
1) Assist in sting operations.
2) Assist in bait & switch operations
3) Identify possible targets
4) Perhaps accept payment for services in the above operations.
Some may actually find ways to compete with other companies.
Source: http://www.abovetopsecret.com/forum/thread791724/pg1
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